Single virus inductively coupled plasma mass spectroscopy analysis: A comprehensive study
نویسندگان
چکیده
The characterisation of individual nanoparticles by single particle ICP-MS (SP-ICP-MS) has paved the way for analysis smallest biological systems. This study suggests to adapting this method viruses (SV) identification and counting. With high resolution multi-channel sector field (MC SF) records in SV detection mode, counting master key ions can allow viruses. 2–500 virial units be performed 20 s. Analyses are proposed carried out Ar torch ions: 12C+, 13C+, 14N+, 15N+, 31P+, 32S+, 33S+ 34S+. All interferences discussed detail. use SF is recommended while options with anaerobic/aerobic atmospheres explored upgrade when using quadrupole ICP-MS. Application two virus types (SARS-COV2 bacteriophage T5) investigated time scan fixed mass selected allowing species N/C, P/C S/C molar ratio's quantification their number concentration.
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ژورنال
عنوان ژورنال: Talanta
سال: 2021
ISSN: ['0039-9140', '1873-3573']
DOI: https://doi.org/10.1016/j.talanta.2021.122211